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Half-life is a mathematical and scientific description of exponential or gradual decay.
Half-life may also refer to:

Biological half-life, the time it takes for a substance to lose half of its pharmacologic, physiologic, or radiologic activity
Effective half-life, the effective radioactive half-life in organisms after accounting for excretion
Halflife (comics), the name of two different Marvel comic characters
Half-Life (novel), a 2004 novel by Aaron Krach
Half Life (novel), a 2006 novel by Shelley Jackson
Half Life (3 album), 2001
Halflife (EP), by Lacuna Coil
Half-Life E.P., by Local H
Half Life: A Parable for the Nuclear Age, a 1985 Australian documentary film